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Related post: LPD, NIAID LPD, NIAID COOPERATING UNITS (i-f tny) LAB/BRAf.CH Laboratory of Parasitic Diseases SECTIOt. Malaria Section INSTITUTE AND LOCATIOr, NIAID, NIH, Bethesda, Maryland 20205 TOTAL MANYEARS: 1.9 PROFESSIONAL! 1.0 OTHER: 0.9 CHECK APPROPRIATE BOx(£S) D («) HUMAN SUBJECTS D («1) MINORS D ('Z) Order Suhagra Online INTERVIEWS D (b) HUMAN TISSUES S (e) NEITHER SUMMARY OF WORK (200 worts or l«ss - underline keyworts) Work has focused on the interaction between the primate malaria Plasmodium cynomolgi and the mosquito Anopheles gambiae , with special attention to factors which cause the normal process of mosquito-parasite infection to fail Two lines of An. gambiae have been selected which are (respectively) refractory and susceptible to infection with P. cynomolgi . Although the lines are not yet pure, preliminary crosses suggest that susceptibility is dominant and inheritance may be monofactorial. Examination of the susceptibility of these two lines to other species of malaria has revealed the same refractoriness/susceptibility pattern with P. knowlesi and P. berghei . Although both lines are susceptible to infection with the human malarias P. vivax and P. falciparum , the refractory line does manifest consistently reduced susceptibility when compared with the non-selected and susceptible lines. 25-36 PHS-6040 (Rev. 2-81) SMITHSONIAN SCIENCE INFORMATION EXCHANGE PROJECT NUMBER (Do HOT use thU spic*; U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES PUBLIC HEALTH SERVICE NOTICE OF IMTRAMURAL RESEARCH PROJECT PROJECT NUMBER ZOl AI 00251-01 LPD PERIOD COVERED October 1. 1981 to September 30. 1982 TITLE OF PROJECT (80 ehtrtcttrs or Itss) Studies on the Immunologic Basis of Resistance in Mice Vaccinated with Irradiated Cercariae NAMES, LABORATORY AND INSTITUTE AFFILIATIONS, AND TITLES OF PRINCIPAL INVESTIGATORS AND ALL OTHER PROFESSIONAL PERSONNEL ENGAGED ON THE PROJECT PI: Others : A. Sher S. L. James R. Oliveira R. Asofsky Head, Cell Biology and Immunology Section Guest Worker Guest Worker Chief LPD, NIAID LPD, NIAID LPD, NIAID LMI, NIAID COOPERATING UNITS (if .ry) Biomedical Research Institute, Rockville, Maryland (Drs. F. Lewis and M. Stirewalt). lab/brai.ch Laboratory of Parasitic Diseases SECT I or. Cell Biology and Immunology Section STITUTE AND LOCATION NIAID, NIH, Bethesda, Maryland 20205 total MANYEARS: 2.3 PROFESSIONAL! 1.6 0.7 check APPROPRIATE BOX(ES) D (•) HUMAN SUBJECTS D («l) MINORS n (•2) INTERVIEWS D (b) HUMAN TISSUES Ug{c) NEITHER SUMMARY OF WORK (200 words or less - underline keywords) lice vaccinated with irradiated cercariae of S. mansoni develop resistance to challenge infection in the absence of overt pathology. In order to identify nechanisms of parasite rejection in this model, mice with genetic or induced immunodeficiencies have been analyzed and Buy Cheap Suhagra compared for their vaccine induced resistance and schistosome specific inunune responses. The results of these studies suggest that in the mouse, vaccine induced immunity is dependent on both B and T lymphocytes and that the effector mechanism of parasite rejection in this model may involve both a humoral and cellular component. Neither
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